C1061S : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-C1059S mutation mimicking human POLD1-C1061S elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Kiktev, D. A. et al. The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe–S cluster in DNA polymerase δ. Nucleic Acids Res 49, 5623–5636 (2021). https://pubmed.ncbi.nlm.nih.gov/34019669/