D402A : Mutation rate in yeast
The Saccharomyces cerevisiae pol3-D407A mutation mimicking human POLD1-D402A elevates the mutation rate strongly in the absence of wild-type POL3 and modestly in the presence of wild-type POL3.
References
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- Jin et al. The 3’ →5’ exonuclease of DNA polymerase δ can substitute for the 5’ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability. Proc Natl Acad Sci USA 98, 5122-5127 (2001). https://pubmed.ncbi.nlm.nih.gov/11309502/
- Herr, A. J. et al. Mutator suppression and escape from replication error-induced extinction in yeast. PLoS Genet 7, e1002282 (2011). https://pubmed.ncbi.nlm.nih.gov/22022273/