D402A : Mutation rate in human cells

Expression of the POLD1-D402A allele in an ovarian cancer cell line elevates the mutation rate when the endogenous wild-type POLD1 is downregulated.

• Ghodgaonkar, M. M. et al. Phenotypic characterization of missense polymerase-δ mutations using an inducible protein-replacement system. Nat Commun 5, 4990 (2014). pubmed.ncbi.nlm.nih.gov/25241845/