D941Y : Tumorigenesis in mice

The mouse Pold1^D939Y mutation mimicking human POLD1-D941Y impairs cell proliferation and embryonic development. There is no evidence of tumorigenic effects.

• Chen, T. et al. A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open 11:bio059307 (2022). https://pubmed.ncbi.nlm.nih.gov/35876795/