D941Y : Biochemical assays

The D941Y substitution in Saccharomyces cerevisiae Pol3 mimicking human POLD1-D941Y reduces the polymerase activity of DNA polymerase δ in vitro.

• Chen, T. et al. A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation. Biol Open 11:bio059307 (2022). https://pubmed.ncbi.nlm.nih.gov/35876795/