E318A : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-E323A mutation mimicking human POLD1-E318A elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Simon, M., Giot, L. & Faye, G. The 3’ to 5’ exonuclease activity located in the DNA polymerase δ subunit of Saccharomyces cerevisiae is required for accurate replication. EMBO J 10, 2165-2170 (1991). https://pubmed.ncbi.nlm.nih.gov/1648480/