The Saccharomyces cerevisiae pol3-E323K mutation mimicking human POLD1-E318K elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.
References:
Ostroverkhova, D. et al. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors. Cell Rep 43, 113655 (2024) https://pubmed.ncbi.nlm.nih.gov/38219146/