The Saccharomyces cerevisiae pol2-G435C mutation mimicking human POLE-G420C does not affect the mutation rate.
References:
Williams, L.N. Emergence of DNA polymerase ε antimutators that escape error-induced extinction in yeast. Genetics 193, 751-770 (2013). https://pubmed.ncbi.nlm.nih.gov/23307893/