L424V : Tumor susceptibility and immune response in mouse models

Homo- and heterozygosity for the Pole^L424V mutation mimicking human POLE-L424V causes cancers with high mutational burden and improved response to immune checkpoint blockade in mice.

References

Sawant, A., et al. Immune checkpoint blockade delays cancer development and extends survival in DNA polymerase mutator syndromes. Cancer Res 85, 1130-1144 (2025). https://pubmed.ncbi.nlm.nih.gov/39786467/