L474P : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-L479P mutation mimicking human POLD1-L474P elevates the mutation rate strongly in the homozygous state and modestly in the heterozygous state.

• Mertz, T.M. Characterization of cancer-associated DNA polymerase δ variants. Ph.D. thesis, University of Nebraska Medical Center (2015). https://digitalcommons.unmc.edu/etd_retro/2093/