P286R : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-P301R mutation mimicking human POLE-P286R causes a strong mutator phenotype in a homozygous or heterozygous state.

• Kane, D.P. & Shcherbakova, P.V. A common cancer-associated DNA polymerase ε mutation causes an exceptionally strong mutator phenotype, indicating fidelity defects distinct from loss of proofreading. Cancer Res 74, 1895-901 (2014). pubmed.ncbi.nlm.nih.gov/24525744/