P696S : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-18 mutation (P710S) mimicking human POLE-P696S causes a mutator phenotype in haploid strains when no wild-type POL2 is present.

• Shcherbakova, P.V., Noskov, V.N., Pshenichnov, M.R., Pavlov, Y.I. Base analog 6-N-hydroxylaminopurine mutagenesis in the yeast Saccharomyces cerevisiae is controlled by replicative DNA polymerases. Mutat. Res., 369, 33-44 (1996). https://pubmed.ncbi.nlm.nih.gov/8700180/