P942L : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-P942L mutation mimicking human POLD1-P942L elevates the mutation rate in haploid strains when no wild-type POL3 allele is present.

• Kokoska, R.J., Stefanovic, L., Demai, J. & Petes, T.D. Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase δ or by decreases in the cellular levels of DNA polymerase δ. Mol Cell Biol 20, 7490-7504 (2000). pubmed.ncbi.nlm.nih.gov/11003646/