R549C : Mutation rate in yeast

The Saccharomyces cerevisiae pol3-R554C mutation mimicking human POLD1-R549C has minimal to no effect on the mutation rate, depending on the reporter gene used.

• Ostroverkhova, D. et al. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors. Cell Rep 43, 113655 (2024) https://pubmed.ncbi.nlm.nih.gov/38219146/