R689W : Mutation rate in human cells

POLD1-R689W expression elevates the mutation rate in the mismatch-repair-deficient HCT116 cell line and its derivative wherein the mismatch repair defect was corrected by microcell-mediated transfer of chromosome 3.

• Mertz, T.M., Baranovskiy, A.G, Wang, J., Tahirov, T.H. & Shcherbakova, P.V. Nucleotide selectivity defect and mutator phenotype conferred by a colon cancer-associated DNA polymerase δ mutation in human cells. Oncogene 36, 4427-4433 (2017). https://pubmed.ncbi.nlm.nih.gov/28368425/