T278K : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-T293K mutation mimicking human POLE-T278K elevates the mutation rate in haploid strains when no wild-type POL2 allele is present.

• Barbari, S.R. Functional characterization of cancer-associated DNA polymerase ε variants. Ph.D. thesis, University of Nebraska Medical Center (2021). https://digitalcommons.unmc.edu/etd/600/