T278M : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-T293M mutation mimicking human POLE-T278M causes a mild increase in the mutation rate in MLH1-deficient strains. It has no mutator effect in mismatch repair-proficient strains.

• Ostroverkhova, D. et al. DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors. Cell Rep 43, 113655 (2024) https://pubmed.ncbi.nlm.nih.gov/38219146/
• Shcherbakova lab, unpublished data.