V411L : Mutation rate in yeast

The Saccharomyces cerevisiae pol2-V426L mutation mimicking human POLE-V411L elevates the mutation rate in MLH1-deficient strains. It has no mutator effect in mismatch repair-proficient strains.

• Barbari, S.R., Kane, D.P., Moore, E.A. & Shcherbakova, P.V. Functional analysis of cancer-associated DNA polymerase ε variants in Saccharomyces cerevisiae. G3 (Bethesda) 8, 1019-1029 (2018). https://pubmed.ncbi.nlm.nih.gov/29352080/
• Barbari, S.R. et al. Enhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels. Nucleic Acids Res 50, 8023-8040 (2022). https://pubmed.ncbi.nlm.nih.gov/35822874/