Y458F : Biochemical assays

The Y473F substitution in Saccharomyces cerevisiae Pol2 mimicking Y458F in human POLE reduces the exonuclease activity of DNA polymerase ε in vitro.

• Dahl, J.M. et al. Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ε. Nucleic Acids Res 50, 962-74 (2022). pubmed.ncbi.nlm.nih.gov/35037018/