POLE : D275V
This variant affects the catalytic amino acid residue in the exonuclease active site of DNA polymerase ε. It eliminates the exonuclease activity of the protein and elevates the mutation rate when modeled in yeast.
This variant affects the catalytic amino acid residue in the exonuclease active site of DNA polymerase ε. It eliminates the exonuclease activity of the protein and elevates the mutation rate when modeled in yeast.