This variant does not elevate the mutation rate when modeled in yeast.
Tsarin L, Shcherbakova PV. PolED: a manually curated database of functional studies of POLE and POLD1 variants reported in humans. Database (Oxford). 2025 Jan 18;2025:baaf076. doi: 10.1093/database/baaf076. PMID: 41263451.