POLD1 : P327L
This variant reduces the exonuclease activity of DNA polymerase δ. It elevates the mutation rate when modeled in mismatch-repair-deficient yeast. It has minimal to no mutator effect in mismatch-repair-proficient yeast.
This variant reduces the exonuclease activity of DNA polymerase δ. It elevates the mutation rate when modeled in mismatch-repair-deficient yeast. It has minimal to no mutator effect in mismatch-repair-proficient yeast.