POLD1 : R506H
This variant mildly elevates the mutation rate in yeast and human cells when combined with a DNA mismatch repair defect. It has no mutator effect in mismatch repair-proficient cells.
This variant mildly elevates the mutation rate in yeast and human cells when combined with a DNA mismatch repair defect. It has no mutator effect in mismatch repair-proficient cells.