POLE : V411L
This variant affects the enzymatic activities of DNA polymerase ε in vitro and tumor susceptibility in mouse models. It causes a mutator phenotype when modeled in DNA mismatch repair-deficient yeast.
This variant affects the enzymatic activities of DNA polymerase ε in vitro and tumor susceptibility in mouse models. It causes a mutator phenotype when modeled in DNA mismatch repair-deficient yeast.